I want to join a group buy for Seti and PGE2, but I'm not in the US, how can I do?
Send me a message at swisstemples@gmail.com for a groupbuy invite.
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How and where can we get PGE2? would it be used just topically? The same question for Setipiprant? where to find, how to use them? and an idea of cost. Congratulations on your knowledge and work by the way.
Read the previous answers. Some people joined groupbuys, some people bought Dinoprostone gel, some are looking for alternatives.
Hi , I am 21Male NW2 , the hairs at my middle-front are still really thin and only growing to a certain extent , ( in german very strohig ) despite taking Finasteride / Ket for over a year , what to do ? Would Seti turn those hairs into Normal hairs ? Can I take Seti oral ?
Seti alone won't regrow your haid it just gets rid of the pgd2 lock. You need to do the full approach. Yes Seti can be taken orally but it's stronger topically.
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Swiss, thank you so bloody much for sharing your work! You may have saved my career! (I'm a model/actor) Im curious: do you think one's success on this regimen is variable to things like size of the area, time spent bald, age, gender? Given your rate of growth when so you envision full restoration?
No none of that really matters. It's going to take longer if your scalp has been bald for 20 years, certainly. But other than that there's no real physiological difference.
You don't like cetirizine. But here it says that http://www.ncbi.nlm.nih.gov/pubmed/7741033 cetirizine enhances PGE2 production. Thoughts?
Cetirizine also inhibits cox1 and cox2 though. If there is a pge2 boosting effect you probably have to find the exact sweet spot between minimal cox inhibition and maximal pge2 expression.
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eisaistomualokatimagiko
Hello, before stepparent, what did you use to lower PGD2 levels?
You mean before setipiprant. Only the Sulfasalazine actually.
What is your opinion about Quercetin? Does it work? Can we use it topically for PGD2 by dissolving it in water and some oil? Thanks
It's rather useless unfortunately. Quercetin does it effect by inhibiting COX which is not what we want.
What shampoo do you recommend?
Very nice , go on! http://imgur.com/XS9J0aK
Haha very cool dude! I actually thought about making a pic like that. Thank you. :)
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Grizzy Bones
Any update on a DIY vehicle? Desperately in need of a vehicle as I don't think I'm ever receiving my CL that's still in customs
I'm using this at 5% successfully right now: 50% ethanol, 30% polysorbate 80, 20% Dimethyl Isosorbide (DMI) and just a drop of DMSO.
I like to add something regard of one of the question , For Dinoprostone( PGE Increaser) Which you mentioned its hard to get and expensive , if you like to get the generic form,I know a great source who has it for around 6 dollars each tube( I can send out the info to Swiss by his request )
That's pretty cool but it's probably one of those 0.75mg per 1ml tubes right? In that case a groupbuy would be a lot cheaper than buying several tubes of that.
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Jordan Belfort
Assuming that with your method you can get 100% density back, does this mean that if someone had gotten a hair transplant and then applied this method their hair density would be at something like 150%?
No that makes no sense lol. Your scalp only grows hair when there is enough space for it. It's not like you can compress and layer them that doesn't work.
I just found this. Apparently an alkaloid extract from Combretum molle Inhibits hematopoietic prostaglandin D2 synthase (H-PGDS). Basically prevents the conversion of PGH2 to PGD2. Do you think it could be useful? http://www.ncbi.nlm.nih.gov/pubmed/24996417
Hey cool find. The common name is "velvet bushwillow". Two problems with this though, it was tested in a petri dish instead of skin. And I couldn't find an extract of that plant for sale from a quick google. I think this could be a great addition if you find a source for it.
Hey Swiss, thank you for your reply :) I have found this one, I think it is really interesting. "AT-56" is an inhibitor of L-PGDS and even better PGD2-blocking compound than inorganic selenium compounds, with half life (12hours) page 7 http://www.jbc.org/content/284/12/7623.full.pdf . Noisette
I've seen that one too actually but it's more expensive than Seti and just as hard to get.
Actually on closer inspection this might be cheaper than Seti given that they use very low doses, however we don't know if this mice dosing directly translates to humans. And we don't have safety studies on humans for it either. Thanks for the study.
Actually on closer inspection this might be cheaper than Seti given that they use very low doses, however we don't know if this mice dosing directly translates to humans. And we don't have safety studies on humans for it either. Thanks for the study.
As soon as winter arrives this part of the world, I'll try your approach. I have trouble getting valproic acid. You have any idea if the more common for, sodium valproate could be used in a similar way?
That's actually just the sodium salted form of valproic acid. Should be fine.
Hey Swiss. I have DUPA. Can your protocol help me? I am really worried. Thanks
I'm not an expert on DUPA so I don't actually know if pgd2 inhibition makes sense for you. But PGE2 is universal when it comes to hair and will benefit you as well. And so would wounding and a progenitor cell boosting substance.
Swiss, are you available for an in-person session to get me going on your regimen/routine once you have it nailed down? Just name your price.
No you don't need to pay me just keep reading my future blog posts and I'll try to make everything as simple as possible. If you don't understand something I'm going to post then just ask on here again and I'll keep improving it until everyone understands it.
I'm interested in what you said about after a while of going through MPB, your skin genetically changes to naturally produce more PDG2. Are you talking about mast cell degranulation? Is there anyway proven to change the balance back to favoring PGE2 in these areas?
There are a few studies showing a related rise in pgd2 to how bald the affected area was, that affinity isn't androgen dependent and that's why we need to block it on the pgd2 level. I don't think the exact chain is known. We do know that healthy hair follicles have pgds suppressing effects in surrounding tissue when estrogen docks to them, so I would put my money on that theory since it fits perfectly with the other studies and phenomenons. But we ultimately don't need to know it to that extent anyway, in fact that already gives us the key for reversal. The more hair still around the less pgd2 expressed by the skin on its own. When we return progenitor cells and initiate new hair growth in a simulated environment of artificially boosted pge2 and blocked pgd2 (+progenitor cells +wounding growth factors and signals) we ultimately end up in a pre mpb conditioned scalp with hair follicles.
Hi, great study, great results! Thanks to you I'm not giving up the hairloss fight just yet. Btw I'm a NW5 thinning for 2 years. But just one question. So basically using seti and pge2 would reserve hairloss? I'm just 1 step away to join a gb for both. Already have a 1mm dermaroller. Thank you
Seti and PGE2 are just two of the four angles. Read the blog fully.
Is the any truth in this?http://www.follacure.com/t/Luteolin , claims luteolin inhibits pdg2 up to %100
Cox inhibitor. Not what we want.
Hey Swiss, Love the blog, I'm definitely interested in improving my regiment by manipulating PGE2 and such. Can you give us a step by step guide as to how to do this with the SPECIFIC products to use and whatnot?
When I get to write on the blog yes. Looks like that will only be on weekends for now.
Hey Swiss, I'm diffuse thinning heavily on top, mainly in the front, my diffuse thinning hasn't been noticeable until a month ago, does your hair loss protocol work on frontal diffuse thinners?
Yes
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monitary1
I take citalopram for depression. Just wanted to check this is hair safe and won't affect my routine. Thanks Swiss
SSRI's in general are not very good for hair but at least they don't affect PGD2. I don't think it will affect you much.
Thanks for your help. Aside setipeprant and real pge2 is there any alternative I could use. Already got castor oil ,sulphasalazine and lithium chloride. Just want to add as much as I can. Also gonna get the selenium shampoo in additon.
Some were mentioned in previous answers. You could also boost pgf2a if you want. But don't go with Bimatoprost, it's weak and expensive. Try to get some Cloprostenol instead.
Based on your previous experience, what strength of tretinoin should I use and how often to avoid negative effects?
I had no good results from it so I can't recommend you any of the failed strengths lol
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