Swisstemple, What kind of castor oil did you use? black or normal transparent (yellowish)? I don't have access to PGE2 powder so I'm using castor oil.
Do not use black castor oil. You want unprocessed cold pressed castor oil.
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Yo I just found your blog and I was reading the questions so I might have a pge2 suggestion http://www.follacure.com/t/emu-oil I've seen lots of people using emu oil with castor oil as a dinamic duo for their hairline so you might want to take look at it :)
The way that study claims it increases pge2 is a bit more on the theoretical side. With castor oil we know that the ricinoleic acid is a real pge2ep3 agonist and it has quite many years of being used as such in different studies. If you want the mix the two go ahead, it can only be beneficial. I'll stick to plain castor oil personally. I'm also gonna get some real pge2 powder soon anyway.
is masturbation ok?
Lol well not according to the bible. But your hair doesn't care.
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Sorry about my English. I have a dermaroller. I easily can find pgd2 and pge2 alternatives like castor oil or sucralfate. But in my country is very hard to buy some lithium. It is only available to mental disorders pacients. Do you know some alternatives to lack of progenitor cells? What about ClO2?
Yes you can get it on ebay, just make sure it's of a high purity. We don't want to use contaminated stuff. Just search for "lithium chloride".
Do Fin/Dut reduce PGD2 activity in the scalp? Since the androgens aren't able to generate as much of an expression receptor and generate as much inflammatory expression, hence reducing PTGDS/PGD2 reaction? Sorry - I've asked a fair few questions. Will be sure to donate.
Yes and no. It reduces the androgen induced PGD2 upregulation but scalp that has already been balding expresses pgd2 on its own as well. We still need to get rid of that bit too. That's why anti androgens work better in people who have just started to bald, their skin isn't expressing that deadlock yet (or at least not fully).
http://www.tandfonline.com.sci-hub.org/doi/abs/10.3109/09546638909086678?journalCode=ijdt20 using topical 5-asa, systematic toxicity is considered unlikely. If I were you I would go for it instead of the sulfa tablets you take daily
Sulfa converts to 5-asa in the body. Or do you mean to forego the added sulfapyridine?
In the Derminator manual, it recommends needling with a 1.5mm only once every 3 or 4 weeks. The studies on dermarolling did it once a week, but I've read it takes longer than that for the wounds to fully heal. How effective might needling only once every 3 weeks be?
Mine are usually healed after about 3 to 4 days. Maybe you're different. Doing it every 3 weeks will make it work... 3 times worse. :D
You say you use a 1.5mm needle when dermaneedling. Is there much chance that 0.5mm needles would be effective? If not, what about 1mm?
0.5 is definitely not long enough. 1mm could do it but I'd stick to 1.5mm since that's what the studies use.
Is miconazole really a pge2 booster ? Can you tell me more about miconazole please ? Thanks :)
No miconazole actually boosts pge1.
thx for reply. How about this one http://www.ebay.com/itm/UVB-Narrowband-311nm-arm-25cm-VITILIGO-PSORIASIS-Acne-SPECIAL-COVER-TESTER-/251923224856?hash=item3aa7cb5918 Is it ok? If yes, it's just once a week for 5 min?
Yeah that's fine. Skin type is different so 3 minutes for one guy might be too much or too little for someone else. It really depends. You want to go for a light sunburn but nothing drastic, if your skin peels it's definitely too much. Try 3 minutes to start with.
Where do you source your Valproic Acid? I found this but not sure about crushing up pills with talc etc; http://www.internationaldrugmart.com/divalproex.shtml And do you think I could add it to Minox (just for the time being)? Doing that with RU atm. Thanks and I hope you're having a nice weekend
I had some stored in the freezer from an old groupbuy. Sodium valproate can be dissolved in ethanol that's no problem. Just make sure the pills you buy have as little other additives as possible. If there's filler then just wait for it to sink to the bottom. Soak the crushed pills in ethanol for at least a day then extract with a syringe. I don't know that site by the way, maybe you want to try inhouse or alldaychemist instead, they have a reputation.
If certain things such as Quercetin block COX, that means they block PGE2 too, then wouldn't it help applying PGE2 topically? By applying topically you are just bypassing the COX effect
That is correct. When you have topical pge2 you could in theory (ab)use cox inhibitors. Wrote about this a bit in previous answers too.
What do you think about Loratadine as PGD2 inhibitor, many studies say that it does inhibit PGD2
Cox inihibitor. Likely the same problem as with Cetirizine.
If we can't call it the cure you are onto, it's a key to a room extremely important for hair loss. I don't want to sound paranoia, but be careful Swiss, it's big business you are overwriting, I don't trust anyone. That you have come to this by yourself, is so freaking cool. Keep up fighting!
It's actually "little business". The only people who profit from hairloss are small to middle sized groups and other weirdos and scammers. And I don't fear any of these losers who take advantage of people's suffering. Merck's Finasteride sales aren't that dependant on hairloss. Their profit is minimal and it's mostly still sold for prostate issues anyway. Minoxidil isn't making upjohn a huge amount of money either since you can get it as a generic.
Mayby i'm not that fast and into the business, but why are people that refers to your progress on hairforum-sites getting banned? Aren't the sites there to help and tell successtorys like yours? Again, Im deeply impressed whit your effort and brainpower.
Shouldn't you be asking the mods and admins there that question? Well some forums are selling their own hair products, which obviously work very little if at all. They are not interested in curing people. Some forums don't want people to talk about non-FDA approved treatments and some people probably just don't like me. I don't really care in the end. I've got my regrowth and the blog is up and filled with information.
Hi Swiss! Basic question about wounding; how are we not sure that mechanical wounding could possibly kill dormant hair? I know as a hair becomes miniaturized, it gets closer to the surface of the skin. Seems possible that you could accidentally stab a dermal papillae.
I've had this thought in the back of my head myself for a very long time. However there are quite a lot of people with diffuse loss who have been rolling for a while and if there was real damage it would make sense for them to get less hair, they do not however. Maybe damaged DP recover from swimming in all that growth factor juice released from the needling.
A reader of your blog talked about Sulcrafate. How would you apply it topically? I would really could use your help on this, have zero experience on mixing stuff up. Ty keep up
Hey, good on you to bring it up again. I've actually looked into it since. The problem is sucralfate is way too big of a molecule to penetrate the skin. We would need micronized sucralfate and that's hard to find. So we would most likely get that from china as well. Which means in the end we might just as well use Setipiprant if we're getting china stuff anyway. Unfortunately doesn't look like it's an easier alternative.
Do you use painkillers before you use your derminator? I've never experienced pain like during the dermaroller sessions
No I just dream of nw0 and bite my teeth lol. You get used to it.
http://i.imgur.com/XOLtHz2.jpg this pic is offline on your blog. Maybe you can see it because your Browser loads it from your browser cache
No it's online
Hi swiss, ty for everything. Can you please post your regime from monday to sunday (e.g. monday morning: applying xyz topically, monday evening dermarolling with 1.5mm and then applying abc topically, tuesday morning ...) on your blog so we can do the same therapy like you?
Yes I'll put it in soon
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I want to exactly follow your protocol. Please let me know where did you buy your stuff from? Castor oil? Sulfasalazine? UV lamps? Derma roller?
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what vectors did you use?
What is this, math class?
Did you take sulfasalizine orally? or did you apply it topically? how?
You cannot use sulfasalazine topically, it's a pro drug. It only gets converted into its active form if you swallow it.
how long did you use UV light? daily? for how many minutes?
Once a week, long enough for a slight sunburn
amazing, which of the things you mentioned did you take orally and which did you apply topically?
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